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目的探讨淋巴结转移的Ⅰb~Ⅱa期维吾尔族妇女子宫颈癌的临床病理相关因素。方法回顾性分析新疆肿瘤医院妇科2004年3月—2010年12月收治的初始治疗行广泛性子宫切除+盆腔淋巴结清扫的Ⅰb~Ⅱa期有完整临床与病理资料的维吾尔族子宫颈癌患者中,选择109例有淋巴结转移的宫颈癌患者作为研究组,另选113例无淋巴结转移患者作为对照组,比较性分析两组患者的年龄,临床分期、肿瘤直径,病理类型、病理分化程度、浸润深度、宫体侵犯,颈管侵犯及脉管内瘤栓情况与淋巴结转移的相关性。结果 (单因素分析结果显示,分化程度差、肿瘤直径大、浸润深度深、脉管有瘤栓、宫体有侵犯、肿瘤出现坏死患者的淋巴结转移情况多见,差异均有显著性(P<0.05)。logistical多因素分析显示浸润深度、分化程度,宫体侵犯,脉管瘤栓是维吾尔族妇女子宫颈癌淋巴结转移的独立危险因素(P<0.05)。结论浸润深度、分化程度,宫体侵犯,脉管瘤栓是维吾尔族妇女子宫颈癌淋巴结转移的主要危险因素,临床上有助于选择必要的处理。
Objective To investigate the clinicopathological factors related to cervical lymph node metastasis in stage Ⅰb ~ Ⅱa Uygur women with lymph node metastasis. Methods The retrospective analysis of gynecological patients from March 2004 to December 2010 in Uigur cervical cancer patients with complete clinical and pathological data from January 1996 to December 2010 in which extensive hysterectomy and pelvic lymphadenectomy were performed in patients with stage Ⅰb ~ A total of 109 patients with cervical cancer with lymph node metastasis were selected as the study group, and 113 patients without lymph node metastasis were selected as the control group. The age, clinical stage, tumor diameter, pathological type, pathological differentiation, depth of invasion , Uterine invasion, cervical invasion and vascular tumor thrombus and lymph node metastasis. Results The results of univariate analysis showed that lymph node metastasis was more common in patients with poor differentiation, large tumor diameter, deep invasion, tumor embolization, invaded uterus and tumor necrosis (P < 0.05) .logistical multivariate analysis showed that depth of invasion, degree of differentiation, uterine invasion, and vascular tumor thrombus were the independent risk factors of cervical lymph node metastasis in Uighur women (P0.05) .Conclusion The depth of invasion, the degree of differentiation, Invasion, vascular tumor embolism is a major risk factor for uterine cervical lymph node metastasis in Uighur women, clinically helpful to choose the necessary treatment.