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在Ⅰ型（姬鼠型、HTN型）疫区人群观察Ⅱ型（家鼠型、SEO型）肾综合征出血热灭活疫苗的免疫效果。共有15101人完成了全程免疫（0、28、42天3针基础免疫及1年后1针加强免疫）。经过1个流行年的观察，接种组无人发病，对照组共发病14例，保护率达100％。基础免疫后14天，IgG抗体（间接免疫荧光法）及中和抗体（微量细胞病变法）阳转率及平均滴度（GMT）分别为71．4％，9．73和62．1％，20.00；加强免疫后14天，阳转率及GMT分别为100％，17．72和96．2％，24．3。接种总反应率为0．52％。主要为发热和局部红肿，分别为0．035％和4.74％，弱、中、强反应率分别为0．46％，0．06％和0％。
To observe the immune effect of Type II (domestic mouse, SEO type) HSV vaccine in type I (Apodemus and HTN) epidemic areas. A total of 15101 people completed the whole immunization (0,28,42 days after the 3-pin immunization and 1 year after the 1-pin boost). After a popular year of observation, vaccination group no one incidence, control group, a total of 14 cases of disease, the protection rate of 100%. On the 14th day after basal immunization, the positive rate and the average titer (GMT) of IgG antibody (Indirect Immunofluorescence) and neutralizing antibody (MCS) were 71.4%, 9.73 and 62.1% respectively, 20.00; 14 days after booster immunization, the positive rate and GMT were 100%, 17.72 and 96.2% respectively, 24.3%. The total inoculation rate was 0.52%. Mainly fever and local redness, were 0.035% and 4.74%, respectively. The rates of weak, moderate and strong reactions were 0.46%, 0.06% and 0% respectively.