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随着细胞毒药物广泛用于治疗肿瘤与非肿瘤疾病,它对骨髓的抑制作用虽引起了临床的重视,但对肺部的毒性作用尚缺乏足够的认识,近年来,细胞毒药物引起肺部病变的国外文献报道较多,本文就其引起肺部病变的有关因素、诊断与防治等问题综述如下: 一、引起肺部病变的药物肺是消除药物的场所,又是药物毒性作用的部位,目前了解能引起肺部病变的细胞毒药物,最常见的有博来霉素、马利兰、氨甲喋呤、卡氮芥、环磷酰胺与丝裂霉毒。
With the widespread use of cytotoxic drugs in the treatment of tumors and non-tumor diseases, its inhibitory effect on bone marrow has drawn clinical attention. However, the toxic effects on the lungs are not sufficiently understood. In recent years, cytotoxic drugs have caused lung Foreign literature reports more lesions, the paper on its causes of lung disease related factors, diagnosis and prevention and treatment of the issues are summarized as follows: First, the cause of pulmonary disease lungs is to eliminate the drug site, but also the site of drug toxicity, Currently understand the cytotoxic drugs that can cause lung lesions, the most common are bleomycin, Maryland, methotrexate, carmustine, cyclophosphamide and mitomycin.