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目的探讨氟尿嘧啶植入剂在原发性晚期上皮性卵巢癌(PAEOC)肿瘤细胞减灭术中的临床疗效。方法回顾性分析安徽医科大学第一附属医院2007年6月至2012年12月收治并成功随访的162例PAEOC患者的临床资料,根据手术关腹前是否植入缓释氟脲嘧啶植入剂将患者分为试验组(术中腹腔植入缓释氟尿嘧啶600 mg)80例和对照组(术中未植入氟尿嘧啶植入剂)82例。观察两组患者的化疗副反应、术后并发症及生存率。结果术后两组化疗副反应差异无统计学意义(P>0.05);试验组与对照组近期生存率差异无统计学意义(χ~2=2.865,P=0.091),而生存率的远期效应,试验组高于对照组,差异有统计学意义(χ~2=4.911,P=0.027)。结论术中植入氟尿嘧啶植入剂是一种安全、有效的腹腔局部化疗方法,可提高患者的远期生存率。
Objective To investigate the clinical efficacy of fluorouracil implants in the cytoreductive surgery of patients with primary advanced epithelial ovarian cancer (PAEOC). Methods The clinical data of 162 patients with PAEOC admitted to the First Affiliated Hospital of Anhui Medical University from June 2007 to December 2012 were retrospectively analyzed. According to whether surgical implanting sustained release fluorouracil Patients were divided into experimental group (intraperitoneal implantation of sustained-release fluorouracil 600 mg) in 80 cases and control group (intraoperative fluorouracil implant was not implanted) in 82 cases. The two groups of patients were observed chemotherapy side effects, postoperative complications and survival rate. Results There were no significant differences in the side effects between the two groups after chemotherapy (P> 0.05). There was no significant difference in the recent survival rates between the two groups (χ ~ 2 = 2.865, P = 0.091) Effect, the experimental group than the control group, the difference was statistically significant (χ ~ 2 = 4.911, P = 0.027). Conclusion Intraoperative implantation of fluorouracil implants is a safe and effective local peritoneal chemotherapy, which can improve the long-term survival rate of patients.