论文部分内容阅读
目的探讨Tenascin、CD34在胆管癌的发生、发展中的作用和意义。方法收集我院1995年-2003年期间切除的胆管癌标本33例和正常胆管组织4例,采用免疫组织化学S-P方法,检测其Tenascin、CD34的表达情况。结果Tenascin在胆管癌组织中的阳性表达率为81.8%(27/33),其中病理分级Ⅰ级、Ⅱ级、Ⅲ级的阳性率分别为71.4%、82.4%和88.9%,但无显著性统计学差异(P>0.05);在正常胆管组织中未检测到Tenascin表达。CD34在胆管癌组织中广泛表达,在正常胆管组织中仅有少量表达,两者相比具有显著统计学差异(P<0.05)。结论Tena-scin可以作为胆管癌的肿瘤标志应用于临床诊断,CD34可作为预测肿瘤转移的一项重要指标。
Objective To investigate the role and significance of Tenascin and CD34 in the occurrence and development of cholangiocarcinoma. Methods Thirty-three cholangiocarcinoma specimens and four normal cholangiocarcinoma specimens from 1995 to 2003 were collected. The expression of Tenascin and CD34 were detected by immunohistochemical S-P method. Results The positive expression rate of Tenascin in cholangiocarcinoma was 81.8% (27/33). The positive rates of pathological grade I, II, and III were 71.4%, 82.4%, and 88.9%, respectively, but there was no statistical significance. Differences (P>0.05); Tenascin expression was not detected in normal bile duct tissue. CD34 was widely expressed in cholangiocarcinoma tissues and was only expressed in normal bile duct tissues. There was a significant difference between the two groups (P<0.05). Conclusion Tena-scin can be used as a tumor marker in cholangiocarcinoma for clinical diagnosis. CD34 can be used as an important index to predict tumor metastasis.