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目的观察苦参素注射液对晚期胃癌化疗患者的免疫调节作用。方法将64例晚期胃癌行TP方案(紫杉醇+顺铂)方案化疗患者分为2组,观察组32例,采用化疗加苦参素注射液联合治疗,对照组32例,即单纯化疗组,观察化疗后两组患者免疫功能(外周血T细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+及NK细胞数目),进行比对分析。结果观察组化疗后外周血CD3+、CD4+、NK细胞数目、CD4+/CD8+比值较化疗前无显著变化(P﹥0.05),对照组化疗后外周血CD3+、CD4+、NK数目、CD4+/CD8+比值较化疗前明显下降(P﹤0.05),CD8+细胞数目较前明显升高(P﹤0.05)。化疗后,观察组外周血CD3+、CD4+、CD4+/CD8+及NK细胞数目较对照组显著升高,差异有统计学意义,(P﹤0.05)。结论晚期胃癌患者化疗时联用苦参素注射液,可以减轻化疗对机体的免疫损伤,增强患者的免疫功能,改善临床症状,改善生活质量。
Objective To observe the effect of oxymatrine injection on patients with advanced gastric cancer chemotherapy. Methods 64 cases of advanced gastric cancer patients undergoing TP regimen (paclitaxel + cisplatin) chemotherapy were divided into two groups, the observation group of 32 patients treated with chemotherapy plus matrine injection, the control group of 32 patients, that is, chemotherapy alone group, observed After chemotherapy, immune function (peripheral blood T cell subsets CD3 +, CD4 +, CD8 +, CD4 + / CD8 + and NK cell number) were compared and analyzed. Results The ratio of CD3 +, CD4 +, NK cells and the ratio of CD4 + / CD8 + in the peripheral blood of the observation group after chemotherapy were not significantly different from those before chemotherapy (P> 0.05) (P <0.05), while the number of CD8 + cells increased significantly (P <0.05). After chemotherapy, the number of CD3 +, CD4 +, CD4 + / CD8 + and NK cells in peripheral blood of the observation group was significantly higher than that of the control group (P <0.05). Conclusions Chemotherapy in patients with advanced gastric cancer combined with oxymatrine injection can reduce the immune damage of chemotherapy on the body to enhance immune function, improve clinical symptoms and improve quality of life.