Protective Effect of Simvastatin on Impaired Intestine Tight Junction Protein ZO-1 in a Mouse Model

• 作 者: 方鑫 徐仁伵
• 机 构: DepartmentofNeurology
• 出 处: Journal of Huazhong University of Science and Technology(Med
• 发表日期: 2015年6期
• 关键词: 辛伐他汀 连接蛋白 保护作用 帕金森病 胃肠道 小鼠 模型 MMP-9 duodenum colon simvastatin tight junction

Recently, several studies showed that gastrointestinal tract may be associated with pathophysiology of Parkinson's disease(PD). Intestine tight junction protein zonula occluden-1(ZO-1) is an important component of intestinal barrier which can be degra