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目的:探讨护肝祛瘀法联合常规保肝西药治疗肝气郁结及血瘀型酒精性肝硬化的临床疗效,为中西医结合治疗酒精性肝硬化提供理论依据。方法:以我院2015年8月~2016年8月收治的60例酒精性肝硬化患者为研究对象,随机分为两组,分别设观察组与对照组,对照组用常规药物治疗,观察组在常规治疗基础上加护肝祛瘀法治疗。比较两组临床疗效、治疗前后中医症候积分、血常规、肝功能、血脂指标及门静脉宽度。结果:观察组治疗总有效率显著高于对照组(90.00%vs70.00%),有统计学意义(P<0.05);治疗前后两组TG、MCV、ALP、AST、ALT、GGT、TBIL差异显著,有统计学意义(P<0.05),对照组ALB无显著性差异(P>0.05),治疗后观察组TG、ALP、AST、GGT、ALB、TBIL与对照组差异显著,有统计学意义(P<0.05),ALT、MCV无显著性差异(P>0.05);治疗前后两组中医症候积分差异显著,治疗后观察组为(15.67±3.56),显著低于对照组(23.54±4.05),有统计学意义(P<0.05),两组治疗前后门静脉宽度无显著性差异,治疗后观察组稍低于对照组但无统计学意义(P>0.05)。结论:相较于常规药物治疗,结合中医护肝祛瘀法治疗能显著提高临床疗效,明显缓解临床症状,能够降低血清生化指标,证明中医药结合治疗酒精性肝硬化疗效更加确切。
Objective: To investigate the clinical curative effect of Hugan Quyu method combined with conventional hepatoprotective western medicine in treating liver cirrhosis and blood stasis type alcoholic cirrhosis, and to provide a theoretical basis for the treatment of alcoholic liver cirrhosis by combining traditional Chinese and western medicine. Methods: Sixty patients with alcoholic cirrhosis who were treated in our hospital from August 2015 to August 2016 were randomly divided into two groups: observation group and control group. The control group was treated with conventional drugs and the observation group On the basis of conventional treatment plus liver stasis therapy. The clinical curative effect, TCM symptom score, blood routine, liver function, blood lipid index and portal vein width before and after treatment were compared. Results: The total effective rate in the observation group was significantly higher than that in the control group (90.00% vs 70.00%, P <0.05). The differences of TG, MCV, ALP, AST, ALT, GGT and TBIL between the two groups before and after treatment There was significant difference between the two groups (P <0.05), but there was no significant difference in the ALB of the control group (P> 0.05). The TG, ALP, AST, GGT, ALB and TBIL in the observation group were significantly different from the control group (P <0.05). There was no significant difference in ALT and MCV between the two groups (P> 0.05). Before and after treatment, the TCM symptom scores were significantly different between the observation group and the control group (15.67 ± 3.56 and 23.54 ± 4.05, (P <0.05). There was no significant difference in the width of portal vein between the two groups before treatment and after treatment, but the observation group was slightly lower than the control group after treatment (P> 0.05). Conclusion: Compared with conventional drug treatment, combined with TCM treatment of liver and stasis removing method can significantly improve clinical curative effect, relieve clinical symptoms and reduce serum biochemical indexes, and prove that Chinese medicine combined with treatment of alcoholic liver cirrhosis has more exact effect.