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目的探讨原发性胆囊癌组织中的基因组变化,寻找与胆囊癌相关的癌基因和抑癌基因的染色体候选区域。方法采用比较基因组杂交方法(CGH)分析28例原发性胆囊癌组织基因组的不平衡即 DNA 的扩增和丢失。结果胆囊癌常见的染色体扩增区域是7p、7q、8q、17q、5p、11q、1q;常见的缺失染色体为17 p、9p、5q、6q、3p、15p、13p。结论胆囊癌中存在多条染色体拷贝数的改变,7p、7q、8q 和17p、9p 等部位可能分别存在与胆囊癌密切相关的癌基因和抑癌基因。
Objective To investigate the genomic changes in primary gallbladder carcinomas and to search for the chromosomal candidate regions of oncogenes and tumor suppressor genes associated with gallbladder carcinomas. Methods The genomic imbalance of 28 cases of primary gallbladder cancer was analyzed by comparative genomic hybridization (CGH), ie, the amplification and loss of DNA. Results The common chromosome amplification regions of gallbladder carcinoma were 7p, 7q, 8q, 17q, 5p, 11q and 1q. The common deletion chromosomes were 17p, 9p, 5q, 6q, 3p, 15p and 13p. Conclusion There are many copies of chromosomes in gallbladder carcinoma. The 7p, 7q, 8q, 17p, 9p and other sites may be closely related to gallbladder carcinomas and tumor suppressor genes, respectively.