论文部分内容阅读
目的研究血清硫氧还蛋白(TRx)、铁蛋白(Fer)、瘦素(Lep)与非酒精性脂肪性肝病的关系。方法应用全自动生化分析仪检测ALT、AST,放射免疫法和ELISA法检测Lep、Fer、TRX。结果非酒精性脂肪性肝病组中TRX、Fer、Lep高于对照组,TRX、Fer、Lep检测值在NASH组中分别为[(66.18±20.96)ng/mL、(350.56±47.06)ng/mL、(16.57±6.88)ng/mL],单纯性脂肪肝组中[(35.72±8.68)ng/mL、(163.98±39.41)ng/mL、(7.68±5.14)ng/mL],正常对照组中[(25.53±6.59)ng/mL、(117.40±31.43)ng/mL、(5.49±4.08)ng/mL]。结论联合动态监测ALT、AST、TRX、Fer、Lep有助于判断肝脏炎症及纤维化状况。
Objective To study the relationship between serum thioredoxin (TRx), ferritin (Fer), leptin (Lep) and non-alcoholic fatty liver disease. Methods ALT, AST were detected by automatic biochemical analyzer, and Lep, Fer and TRX were detected by radioimmunoassay and ELISA. Results The levels of TRX, Fer and Lep in non-alcoholic fatty liver disease group were higher than those in control group. The values of TRX, Fer and Lep were (66.18 ± 20.96) ng / mL and (350.56 ± 47.06) ng / mL in NASH group , (16.57 ± 6.88) ng / mL] in the fatty liver group [(35.72 ± 8.68) ng / mL, (163.98 ± 39.41) ng / mL, [(25.53 ± 6.59) ng / mL, (117.40 ± 31.43) ng / mL, (5.49 ± 4.08) ng / mL]. Conclusions Combined dynamic monitoring of ALT, AST, TRX, Fer, Lep can help determine liver inflammation and fibrosis.