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目的探讨妊娠期高血压疾病与甲状腺功能减低的相关性。方法将200例妊娠期高血压患者作为观察组,根据患者临床表现将患者分为单纯高血压组、轻度子痫前期组和重度子痫前期组。选取同期健康妊娠孕妇120例作为对照组,观察患者血清促甲状腺激素(TSH)、游离甲状腺素(FH_4)和甲状腺过氧化物酶抗体(TPO-Ab)水平以及与高血压严重程度相关性。结果 1观察组患者血清TSH明显高于对照组(P<0.05);重度子痫前期组明显高于轻度子痫前期组以及单纯高血压组(P<0.05);观察组血清FT_4水平明显高于对照组(P<0.05);观察组内FT_4水平差异无统计学意义(P>0.05);TPO-Ab浓度各组差异无统计学意义(P>0.05);2观察组总甲状腺功能异常发生率明显高于对照组(P<0.05);3观察组患者血清FH_4、TPO-Ab与疾病严重程度无关(P>0.05),而TSH与疾病严重程度呈正相关(OR=1.53,95%CI:1.316~1.725)。结论甲状腺功能减低与妊娠期高血压疾病有关,参与因子主要为促甲状腺激素。
Objective To investigate the relationship between hypertensive disorders of pregnancy and hypothyroidism. Methods 200 cases of hypertensive patients with pregnancy as the observation group, according to the clinical manifestations of patients were divided into simple hypertension group, mild preeclampsia group and severe preeclampsia group. A total of 120 healthy pregnant women of the same period were selected as the control group. Serum levels of thyroid stimulating hormone (TSH), free thyroxine (FH 4) and thyroid peroxidase (TPO-Ab) were measured and their correlations with the severity of hypertension were observed. Results The level of serum TSH in the observation group was significantly higher than that in the control group (P <0.05); the level of FT_4 in the severe preeclampsia group was significantly higher than that in the mild preeclampsia group and the simple hypertension group (P <0.05) (P <0.05). There was no significant difference in the FT_4 level in the observation group (P> 0.05). There was no significant difference in the concentration of TPO-Ab between the two groups (P> 0.05) .2 The total thyroid function abnormalities The serum levels of FH 4 and TPO-Ab in the observation group were not related to the severity of the disease (P> 0.05), but TSH was positively correlated with the severity of the disease (OR = 1.53, 95% CI: 1.316 ~ 1.725). Conclusions Hypothyroidism is associated with hypertensive disorder complicating pregnancy. The main contributing factors are thyrotropin.