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目的 :观察羟基喜树碱 (HCPT)加醛氢叶酸 (CF)加 5 -氟脲嘧啶 (5 - Fu)方案治疗晚期大肠癌的疗效与毒副作用。方法 :1999年 7月～ 2 0 0 2年 5月我科收治晚期大肠癌 6 8例 ,随机分为两组 ,各 34例。治疗组予以 HCPT加 CF加 5 - Fu化疗 ;对照组予以 CF加 5 - Fu化疗。结果 :治疗组有效率为 5 2 .9% ,其中完全缓解 2例 ;对照组有效率为 32 .4 % ,两组比较差异有显著性意义 (P <0 .0 5 )。治疗组的白细胞下降 4 1.0 % ,高于对照组的 2 6 .5 % ,差异有显著性意义 (P <0 .0 5 ) ,但其下降分度 5 7.1%为 度。结论 :HCPT加 CF加 5 - Fu方案能显著提高晚期大肠癌化疗的有效率 ,其毒副作用基本能耐受
Objective: To observe the curative effect and side effects of HCPT combined with 5 - fluorouracil and 5 - fluorouracil (5 - Fu) in the treatment of advanced colorectal cancer. Methods: From July 1999 to May 2002, 68 patients with advanced colorectal cancer were treated in our department. They were randomly divided into two groups (34 in each). The treatment group received HCPT plus CF plus 5 - Fu chemotherapy; the control group received CF plus 5 - Fu chemotherapy. Results: The effective rate of the treatment group was 52.9%, of which 2 cases were completely relieved. The effective rate of the control group was 32.4%. There was significant difference between the two groups (P <0.05). The leukopenia in the treatment group was 4.01%, which was significantly higher than that in the control group (P <0.05), but the descending degree was 51.1%. Conclusion: HCPT plus CF plus 5 - Fu regimen can significantly improve the chemotherapy efficiency of advanced colorectal cancer, and its toxicity and side effects are basically tolerable