Birth defects in pregestational diabetes： Defect range,glycemic threshold and pathogenesis

• 作 者: Rinat Gabbay-Benziv E Albert R
• 机 构: DepartmentofObstetrics,DepartmentofBiochemistryandMolecularBiology
• 出 处: 世界糖尿病杂志：英文版（电子版）
• 发表日期: 2015年3期
• 关键词: Pregestational diabetes BIRTH defects Glycemic THRESHOLD DIABETIC embryopathy RA
• 基金项目: Supported by NIH R01DK083243,R01DK101972 and R56 DK095380(to Yang P),R01DK103024(to Yang P and Reece EA),Basic Science Award(1-13-BS-220),American Diabetes Association(to Yang P)

Currently, 60 million women of reproductive age（18-44 years old） worldwide, and approximately 3million American women have diabetes mellitus, andit has been estimated that this number will doubleby 2030. Pregestational diabetes mellitus （PGD） is asignific