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目的与方法 :本实验采用全胚胎培养方法 ,建立了环磷酰胺致畸作用模型 ,并在此基础上利用流式细胞分析术对培养所得胚胎进行了细胞学观察与分析。结果与结论 :发现环磷酰胺所致胚胎畸形可能与其所引起的细胞周期改变及细胞凋亡有关。
OBJECTIVE AND TEST: The model of teratogenicity of cyclophosphamide was established by whole embryo culture in this experiment. Cytological observation and analysis of the obtained embryos were performed by flow cytometry. RESULTS AND CONCLUSION: It was found that embryonic malformations caused by cyclophosphamide may be related to cell cycle changes and apoptosis induced by cyclophosphamide.