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目的：探讨内胚窦瘤的病理学特点。方法：采用常规病理技术及免疫组织化学方法，研究４０例内胚窦瘤患者，其中３２例发生于卵巢，８例发生于睾丸。结果：组织学表现有５种，网状结构、透明小体、腺样结构、内胚窦样结构和实体状结构，前３种可作为诊断标准。免疫组织化学染色结果：兔抗人单克隆甲胎蛋白（ＡＦＰ）、抗胰蛋白酶（ＡＡＴ）均为阳性，绒毛膜促性腺激素（ＨＣＧ）和癌胚抗原（ＣＥＡ）均为阴性。结论：不同的组织结构特征及免疫组织化学表现，有助于对内胚窦瘤的诊断。
Objective: To investigate the pathological features of endodermal sinus tumors. METHODS: Forty cases of endodermal sinus aneurysms were studied by conventional pathology techniques and immunohistochemical methods. Of these, 32 cases occurred in the ovary and 8 cases occurred in the testis. RESULTS: There were 5 histological manifestations, reticular formations, clear bodies, adenoid structures, endosperm-like structures, and solid-like structures. The first three were used as diagnostic criteria. Immunohistochemical staining showed that rabbit anti-human alpha-fetoprotein (AFP) and anti-trypsin (AAT) were positive, and chorionic gonadotropin (HCG) and carcinoembryonic antigen (CEA) were negative. Conclusion: Different histological features and immunohistochemical findings contribute to the diagnosis of endodermal sinus tumors.