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作者在一系列致癌实验中,偶然发现农药秋兰姆TMTD对白血病及某些脏器的自发肿瘤有抑制现象。本文以作者的实验结果为重点,对抑制自发肿瘤的化合物予以介绍。 秋兰姆是二硫化四甲基秋兰姆的简称,为橡胶硫化促进剂及杀虫杀菌剂。其类似物二硫化四乙基秋兰姆(TETD)是有名的戒酒药,也是橡胶促进剂;另一类似物二甲基二硫化氨基甲酸锌,即著名农药福美锌。 TMTD毒性不大,小鼠经口LD_(50)为1500～2000mg/kg,大鼠为560mg/kg。Ames试验对TA100菌显示致变性,重组修复试验及大鼠染色体异常试验
In a series of carcinogenic experiments, the authors occasionally discovered that the pesticide Thiuram TMTD inhibits the spontaneous tumor of leukemia and some organs. This article focuses on the authors’ experimental results and describes compounds that inhibit spontaneous tumors. Thiuram is short for tetramethyl thiuram disulfide, a rubber vulcanization accelerator and insecticide fungicide. Its analogues Tetraethylthiuram disulfide (TETD) is a famous anti-alcohol drug, but also a rubber accelerator; another analog of dimethyl disulfide Zinc carbamate, known as pesticide Fume zinc. TMTD toxicity is not large, mouse oral LD_ (50) of 1500 ~ 2000mg / kg, rat 560mg / kg. Ames test showed TA100 bacteria degeneration, recombinant repair test and rat chromosomal abnormalities test