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应用ＡＰＡＡＰ免疫酶桥法及双抗体夹心ＥＬＩＳＡ法测定１５１例慢性乙型肝炎患者外周血Ｔ淋巴细胞亚群和血清可溶性白细胞介素－２受体（ＳＩＬ－２Ｒ）。结果显示，慢乙肝患者ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８比值明显降低，ＣＤ８则明显升高。表明慢乙肝患者体内存在Ｔ淋巴细胞比例失衡，细胞免疫调控功能紊乱。慢乙肝患者血清ＳＩＬ－２Ｒ水平均显著升高，其中以慢重肝和慢活肝升高最为显著，提示ＳＩＬ－２Ｒ水平高低能反映机体免疫功能状态及肝细胞损伤程度。Ｔ细胞亚群和ＳＩＬ－２Ｒ联合检测对慢乙肝患者病值变化、临床诊断分型及预后判断有重要价值。
The peripheral blood T-lymphocyte subsets and serum soluble interleukin-2 receptor (SIL-2R) were measured in 151 patients with chronic hepatitis B using APAAP immunoenzyme bridge assay and double antibody sandwich ELISA. The results showed that patients with chronic hepatitis B CD3, CD4, CD4 / CD8 ratio was significantly lower, CD8 was significantly higher. That the body of patients with chronic hepatitis B in the presence of an imbalance in T lymphocytes, cellular immune regulation disorder. Serum SIL-2R levels were significantly increased in patients with chronic hepatitis B, of which the most significant was chronic severe hepatitis and slow-lived liver, suggesting that the level of SIL-2R may reflect the immune function and the degree of hepatocyte damage. T cell subsets and SIL-2R joint detection of chronic hepatitis B patients with changes in the value of clinical diagnosis and prognosis of important value.