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目的探讨TGF-β1在隐匿性乙型肝炎病毒感染发病机制中的意义和作用。方法采用酶联免疫法(ELISA)分别测定健康对照组40例、HBV组38例以及OBI组78例的血清TGF-β1值,并分析其与ALT、乙肝血清学标志物之间的相关性。结果 OBI组血清TGF-β1水平较健康对照组升高(F=4.311,P<0.05),而HBV组较健康对照组无统计学差异(F=2.242,P>0.05);OBI组血清中TGF-β1水平在ALT≤20 U/L和20 U/L0.05);OBI组血清中TGF-β1与乙肝血清学标志物之间无相关性。结论血清中TGF-β1表达水平与OBI持续感染存在一定联系,其含量变化与肝脏炎症程度、乙肝血清学标志物无相关性。
Objective To investigate the significance and role of TGF-β1 in the pathogenesis of occult hepatitis B virus infection. Methods The levels of serum TGF-β1 in 40 healthy subjects, 38 in HBV group and 78 in OBI group were determined by enzyme-linked immunosorbent assay (ELISA), and their correlation with ALT and hepatitis B serological markers were analyzed. Results Serum levels of TGF-β1 in OBI group were significantly higher than those in healthy control group (F = 4.311, P <0.05), but no significant difference was found between HBV group and healthy controls (F = 2.242, P> 0.05) There was no significant difference in the level of -β1 between ALT≤20 U / L and 20 U / L 0.05) No correlation between markers. Conclusion The serum level of TGF-β1 is associated with persistent infection of OBI. The content of TGF-β1 in serum has no correlation with the extent of liver inflammation and hepatitis B serological markers.