金属/质子酸协同催化炔酮环化构建桥环产物

• 出 处: 有机化学
• 发表日期: 2015年09期
• 关键词: 协同催化 桥环 质子酸 生物活性分子 有机合成 有机化学 天然产物 化合物 环化 金属

Angew.Chem.Int.Ed.2015,54,9414~9418协同催化是一种强大的催化策略,广泛应用于现代有机合成中.高张力双环[3.n.1]体系是很多天然产物和生物活性分子的核心骨架,如何快速、高效构建此类桥环骨架是有机化学中的一个挑战课题.最近,华南理工大学祝诗发教授课题组利用金属/质子酸协同催化策略,成功实现了炔酮化合物的分子内环化,一步构建了双环[3.n.1]烷酮化合

Angew.Chem.Int.Ed.2015,54,9414 ~ 9418 Synergistic catalysis is a powerful catalytic strategy and is widely used in modern organic synthesis.High-tension bicyclo [3.n.1] systems are a great many natural products and organisms How to construct such bridge-ring framework quickly and efficiently is a challenge in organic chemistry.Recently, the research group of Professor Zhu Shifa of South China University of Technology, using the metal / protonic acid synergistic catalysis strategy, has succeeded in realizing the alkynone compound Intramolecular cyclization, one-step construction of bicyclo [3.n.1] alkanone compounds