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Lung injury induced by phospholipase A_2(PLA_2,0.046 IU/ml perfusate) was studied in a continuous weighing system of isolated perfused guinea pig lungs. The results revealed that lung weight increased progressively during the 30 min perfusion of PLA_2. No change of pulmonary arterial pressure was observed in the same period. Albumin permeability-surface area product. lung index, lung water content, exudate from pleura, and angiotensin-converting-enzyme activity increased significantly at the
Lung injury induced by phospholipase A_2(PLA_2,0.046 IU/ml perfusate) was studied in a continuous weighing system of isolated perfused guinea pig lungs. The results revealed that lung weight posed progressively during the 30 min perfusion of PLA_2. No change of pulmonary arterial Image was observed in the same period. Albumin permeability-surface area product. lung index, lung water content, exudate from pleura, and angiotensin-converting-enzyme activity increased significantly at the