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目的探讨血清胆碱酯酶(CHE)、前白蛋白(PA)和总胆汁酸(TBA)检测在对肝硬化患者病情严重程度及预后评价中的临床意义。方法对96例肝硬化患者和50例健康体检者进行CHE、PA、TBA及常规肝功能生化检测并进行比较。结果肝硬化患者血清CHE〔(2887.0±845.4)vs(7556.0±925.2)U/L,P<0.01〕、PA〔(155.9±31.4)vs(289.2±51.3)mg/L,P<0.01〕均明显低于正常对照组,TBA明显高于对照组〔(40.1±23.1)vs(4.8±1.9)mmol/L,P<0.01〕,且随Child-Pugh分级的级别增高,变化更趋明显。结论血清CHE、PA、TBA活性检测对判断肝硬化疾病严重程度具有重要的指导意义,可作为肝硬化患者病情判断和预后判断的指标。
Objective To investigate the clinical significance of detecting serum cholinesterase (CHE), prealbumin (PA) and total bile acid (TBA) in evaluating the severity and prognosis of cirrhotic patients. Methods The biochemical tests of CHE, PA, TBA and routine liver function in 96 patients with cirrhosis and 50 healthy subjects were performed and compared. Results Serum levels of CHE in patients with cirrhosis (2887.0 ± 845.4 vs 7556.0 ± 925.2 U / L, P <0.01), PA 〔(155.9 ± 31.4) vs (289.2 ± 51.3) mg / L, P <0.01〕 The TBA was significantly lower than that of the control group [(40.1 ± 23.1) vs (4.8 ± 1.9) mmol / L, P <0.01〕, and the level of Child-Pugh was higher than that of the control group. Conclusions The detection of serum CHE, PA and TBA activity has important guiding significance for judging the severity of cirrhosis. It can be used as an indicator of disease judgment and prognosis in cirrhotic patients.