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为了控制癌痛，观察硫酸吗啡控释片治疗癌痛的疗效，作者于１９９５年２月至１９９６年５月用硫酸吗啡控释片治疗中、重度癌痛４８例。结果：镇痛的显著有效率（完全＋中度缓解）和有效率分别为７９．２％（３８／４８）和９１．７％（４４／４８）；疼痛的程度减轻，治疗后疼痛级数（３．６±１．４）小于治疗前（７．８±１．２，Ｐ＜０．０５）；生活质量有明显改善，治疗后Ｋａｒｎｏｆｓｋｙ评分（６７±９）高于治疗前（３９±１１，Ｐ＜０．０５），副作用主要为便秘。结果提示：硫酸吗啡控释片在第三阶梯镇痛药中作为首选药，具有较好的临床应用价值。
In order to control cancer pain, we observed the efficacy of morphine sulfate controlled-release tablets in the treatment of cancer pain. From February 1995 to May 1996, 48 patients with moderate to severe cancer pain were treated with morphine sulfate controlled-release tablets. Results: The effective rate (complete + moderate remission) and effective rate of analgesia were 79.2% (38/48) and 91.7% (44/48) respectively; the degree of pain relief, the pain grade after treatment (3.6 ± 1.4) were lower than those before treatment (7.8 ± 1.2, P <0.05), and the quality of life improved significantly. The Karnofsky score (67 ± 9) after treatment was higher than that before treatment 11, P <0.05), the main side effects of constipation. The results suggest that: morphine sulfate controlled-release tablets in the third step analgesic drugs as the preferred drug, has good clinical value.