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为了探讨活性氧与破骨细胞活性的相关性 ,以进一步阐明活性氧与骨质疏松症的内在联系 ,选择符合纳入标准的绝经后妇女 ,测定其骨密度 (BMD) ,根据骨密度分为骨质疏松组、骨量减少组及正常组各 30例。检测各组研究对象的血清丙二醛(MDA)、超氧化物歧化酶 (SOD)及抗酒石酸盐酸性磷酸酶 (TRAP) ,比较各组之间的MDA、SOD及TRAP的不同并分析MDA、SOD与TRAP的相关性。结果显示MDA与TRAP呈正相关 (r=0 .6 13,P <0 .0 1) ,SOD与TRAP呈负相关 (r = 0 .733,P <0 .0 1) ;骨质疏松组、骨量减少组的血清MDA水平较正常组高而SOD含量降低 ,骨质疏松组的MDA和SOD亦较骨量减少组升高和降低 (P <0 .0 1)。这些结果说明活性氧能提高破骨细胞的活性 ,体内活性氧水平升高 ,进而使破骨细胞活性增强 ,可能是绝经后骨质疏松症发生的重要原因之一。
In order to explore the relationship between reactive oxygen species and osteoclast activity, in order to further clarify the intrinsic relationship between reactive oxygen species and osteoporosis, select postmenopausal women who meet the inclusion criteria, determine the bone mineral density (BMD), according to the bone mineral density is divided into bone Osteoporosis group, osteopenia group and normal group of 30 cases. The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and tartrate-resistant acid phosphatase (TRAP) in serum of each group were measured. The differences of MDA, SOD and TRAP between groups were analyzed and MDA, Correlation between SOD and TRAP. The results showed that there was a positive correlation between MDA and TRAP (r = 0.133, P <0.01), and negative correlation between SOD and TRAP (r = 0.333, P <0.01) Compared with the normal group, the content of MDA in the serum decreased and the content of MDA in the osteoporosis group decreased (P <0.01). These results suggest that ROS can increase the activity of osteoclasts, increase the level of reactive oxygen species in the body and further enhance the activity of osteoclasts, which may be one of the important causes of postmenopausal osteoporosis.