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目的分析环氧合酶-2(COX-2)和PTEN蛋白在卵巢上皮肿瘤中的表达及其意义。方法采用免疫组织化学SP法检测48例卵巢癌、15例卵巢交界性肿瘤、16例卵巢良性肿瘤组织中COX-2和PTEN表达情况,同时选取10例正常卵巢组织作为对照。结果 COX-2在卵巢上皮性癌和交界性肿瘤组织中的表达率明显高于卵巢良性肿瘤及正常组织,差异有统计学意义(P<0.05);COX-2在卵巢上皮性癌组织中的表达与淋巴结转移有明显相关性(P<0.05),而与组织学分级、临床分期、组织学类型无明显相关(P>0.05);PTEN蛋白在卵巢癌组织和卵巢交界性肿瘤中表达明显低于卵巢良性肿瘤和正常卵巢组织,差异有统计学意义(P<0.05);PTEN蛋白表达与卵巢癌与组织学分级、临床分期和淋巴结转移明显相关(P<0.05),而与组织学类型无明显相关(P>0.05)。结论 COX-2的表达上调和PTEN表达降低或缺失在卵巢癌的发生、发展中可能起重要作用。
Objective To analyze the expression of cyclooxygenase-2 (COX-2) and PTEN protein in epithelial ovarian tumors and its significance. Methods Immunohistochemical SP method was used to detect the expression of COX-2 and PTEN in 48 cases of ovarian cancer, 15 cases of ovarian borderline tumors and 16 cases of benign ovarian tumors. Meanwhile, 10 cases of normal ovarian tissue were selected as the control. Results The expression of COX-2 in epithelial ovarian tumor and borderline tumor was significantly higher than that in benign ovarian tumor and normal tissue (P <0.05). The expression of COX-2 in epithelial ovarian cancer The expression of PTEN protein was significantly correlated with lymph node metastasis (P <0.05), but not with histological grade, clinical stage and histological type (P> 0.05). PTEN protein was significantly lower in ovarian cancer and borderline ovarian tumors (P <0.05). The expression of PTEN protein was significantly correlated with histological grade, clinical stage and lymph node metastasis (P <0.05), but not with histological type Significantly related (P> 0.05). Conclusion The up-regulation of COX-2 and the decrease or deletion of PTEN expression may play an important role in the occurrence and development of ovarian cancer.