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目的:制备硝苯地平速释片,增加其溶出度。方法:以聚乙二醇(PEG6000)和聚乙烯吡咯烷酮(PVPk30)为载体,溶剂法和溶剂熔融法制备固体分散体,差示热分析鉴别药物在载体中的存在状态,测定片剂溶出度。结果:硝苯地平能与PVPk30、PEG6000两种栽体形成固体分散体,制备的片剂溶出度均大于80%,以PVPk30-NF固体分散体所制速释片溶出度最快、最多。结论:PEG6000、PVPk30作为制备硝苯地平速释片的固体分散体的栽体.增溶效果显著,且PVPk30优于PEG6000。
OBJECTIVE: To prepare nifedipine immediate release tablets and increase its dissolution rate. Methods: The solid dispersions were prepared by solvent method and solvent fusion method using polyethylene glycol (PEG6000) and polyvinylpyrrolidone (PVPk30) as carriers. Differential thermal analysis (DTA) was used to identify the presence of drug in the carrier. Results: Nifedipine could form a solid dispersion with PVPk30 and PEG6000. The dissolution rate of the prepared tablets was more than 80%. The dissolution rate of the tablets was the fastest with the PVPk30-NF solid dispersion. Conclusion: PEG6000 and PVPk30 are good carriers for the preparation of solid dispersion of nifedipine immediate release tablets, and the solubilization effect is remarkable, and PVPk30 is better than PEG6000.