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目的以对失去手术根治放疗条件及不宜大剂量化疗的中、晚期非小细胞肺癌(NSCLC)和晚期肾癌患者为研究对象,观察泥蚶提取物-海生素制剂治疗NSCLC和肾癌的疗效。方法海生素2.4mg+0.9%氯化钠250ml,静脉滴注,每日1次,连用20,28d为1周期,连用3~6个周期,同时观察海生素制剂的毒副作用。结果61例NSCLC患者中CR 2例,PR 28例,近期总有效率为49.18%。初治患者疗效显著高于复治患者(P<0.05),Ⅲb患者疗效显著高于Ⅳ患者(P<0.05),腺癌显著高于鳞癌(P<0.01),行为状态高者近期疗效明显好于行为状态低者(P<0.01)。27例肾癌患者中,CR 1例,PR 12例,SD 9例,PD 4例。总有效率为48.15%,其中1例CR已无病生存48个月,所有患者均未出现严重的毒副反应。结论海生素制剂治疗中、晚期NSCLC和晚期肾癌疗效明显,毒副作用小,安全有效。
Objective To investigate the curative effect of Scutellariae Radix - seawater extract in the treatment of NSCLC and renal cell carcinoma in patients with advanced non-small cell lung cancer (NSCLC) and advanced renal cell carcinoma who have undergone surgery without radiotherapy and high-dose chemotherapy. . Methods Hydrochloric acid 2.4mg + 0.9% sodium chloride 250ml, intravenous infusion, once daily, once every 20, 28d for 1 cycle, once every 3 to 6 cycles, while observing the toxic side effects of the preparation of seawater. Results 61 cases of NSCLC in CR 2 cases, PR 28 cases, the recent total effective rate was 49.18%. The curative effect of newly diagnosed patients was significantly higher than that of retreatment patients (P <0.05), the curative effect of Ⅲb patients was significantly higher than that of patients with Ⅳ (P <0.05), adenocarcinoma was significantly higher than that of squamous cell carcinoma (P <0.01) Better than those with lower status (P <0.01). Of 27 patients with renal cell carcinoma, 1 was CR, 12 were PR, 9 were SD and 4 were PD. The total effective rate was 48.15%. One of the patients had no disease for 48 months and none of the patients had any serious side effects. Conclusion The treatment of mid-term and advanced NSCLC and advanced renal cell carcinoma has obvious curative effect, small toxic and side effect, safe and effective.