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[目的 ]探讨钼对汞遗传毒性的影响。 [方法 ]观察采用腹腔注射钼酸钠和氯化汞联合染毒对小鼠骨髓多染红细胞微核率的影响。 [结果 ]连续 4天给小鼠注射 Hg Cl2 〔1.0 mg/ kg (bw)〕的同时注射 10、 10 0 mg/ kg(bw)〕的 Na2 Mo O4可显著降低 Hg Cl2 的致小鼠微核率 (P<0 .0 0 1) ;在 Hg Cl2 〔1.0 mg/ kg (bw)〕给小鼠染毒前 3天连续注射 10 0 mg/ kg(bw) Na2 Mo O4可显著地降低 Hg Cl2 所致微核率 ;在 Hg Cl2 〔1.0 mg/ kg(bw)〕给小鼠染毒后连续 3天注射 Na2 Mo O4,Hg Cl2 致微核率下降不显著 (P>0 .0 5 )。 [结论 ]钼对汞的遗传毒性有拮抗作用
[Objective] To investigate the effect of molybdenum on the genotoxicity of mercury. [Method] To observe the effect of intraperitoneal injection of sodium molybdate and mercuric chloride on the micronuclei rate of mouse erythrocytes. [Result] The mice were injected with 10, 100 mg / kg (bw) of Na2 Mo O4 simultaneously for 4 days while injecting Hg Cl2 [1.0 mg / kg (bw)] into mice. (P0.01). Continuous injection of 10 0 mg / kg (bw) Na2 Mo O4 three days before Hg Cl2 [1.0 mg / kg (bw)] in mice significantly reduced Hg Cl2 (P> 0.05). The micronucleus rate of Hg Cl2 did not decrease significantly (P> 0.05) after injecting Na2 Mo O4 for 3 days in mice treated with Hg Cl2 [1.0 mg / kg (bw)]. [Conclusion] Molybdenum has an antagonistic effect on the genotoxicity of mercury