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目的 S探究血管内皮生长因子(VEGF)及肿瘤标志物水平在食管癌患者血清中的表达及临床意义。方法接受放疗的食管癌患者51例,根据放疗效果分为有效组(37例)与无效组(14例),选35例同期健康体检者作为对照组,均测定血清肿瘤标志物、缺氧诱导因子-1α(HIF-1α)及VEGF水平,分析放疗前、中、后VEGF与血清肿瘤标志物、HIF-1α相关性。结果研究组放疗前、中、后血清肿瘤标志物、HIF-1α及VEGF水平均显著高于对照组,放疗过程中上述指标均低于放疗前,放疗后高于放疗中但仍低于放疗前(P<0.05);与无效组相比,有效组血清肿瘤标志物、HIF-1α及VEGF水平均明显较低(P<0.05);放疗前、中、后各阶段VEGF水平与血清肿瘤标志物、HIF-1α均呈明显正相关(P<0.05)。结论食管癌患者放疗可明显影响VEGF水平与血清肿瘤标志物水平,放疗前后二者水平均先降后升,可有效评估放疗效果及预后。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) and tumor marker in the serum of patients with esophageal cancer and its clinical significance. Methods Fifty-one patients with esophageal cancer undergoing radiotherapy were divided into two groups based on radiotherapy: effective group (37 cases) and ineffective group (14 cases), and 35 healthy controls were selected as control group. Serum tumor markers, hypoxia-induced Factor-1α (HIF-1α) and VEGF levels before and after radiotherapy, VEGF and serum tumor markers, HIF-1α correlation. Results The levels of serum tumor markers, HIF-1α and VEGF in study group before radiotherapy, after radiotherapy and after radiotherapy were significantly higher than those in the control group. The above indexes during radiotherapy were lower than those before radiotherapy, but higher than radiotherapy but still lower than radiotherapy (P <0.05). Compared with the ineffective group, the levels of serum tumor markers, HIF-1α and VEGF in the effective group were significantly lower (P <0.05). The levels of VEGF in the effective group were significantly correlated with serum tumor markers , HIF-1α were positively correlated (P <0.05). Conclusion The radiotherapy of patients with esophageal cancer can significantly affect the level of VEGF and serum tumor markers, both before and after radiotherapy levels first and then rise, which can effectively evaluate the radiotherapy effect and prognosis.