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Gugulipid是印度药用植物Commiphoramakul(Burseraceae)的油状树脂(在印度北部通常称为Guggul)的标准化提取物。gugulipid的活性组分主要是Guggulsterone(Z式和E式两个异构体)。药理作用 Gugulipid是一有效的降脂药,从高血脂病人和动物实验中已显示了它具有明显的降低胆固醇和脂类的活性。在兔子,Gugulipid也能预防动脉硬化,并有助于动脉粥样化损伤的消除。在大鼠,Gugulipid对异丙基肾上腺素诱导的心肌坏死有防护作用。动物研究也表明Gugulipid对肾上腺素导致的血小板凝集有
Gugulipid is a standardized extract of the oily resin of Commiphoramakul (Burseraceae), an Indian medicinal plant commonly known as Guggul in northern India. The active ingredient of gugulipid is mainly Guggulsterone (both Z and E isomers). Pharmacological Gugulipid is a potent lipid-lowering drug which has been shown to have significant cholesterol and lipid lowering activity in hyperlipidemic and animal experiments. In rabbits Gugulipid also prevents atherosclerosis and contributes to the elimination of atherosclerotic lesions. Gugulipid has a protective effect on isoproterenol-induced myocardial necrosis in rats. Animal studies have also shown that Gugulipid has an effect on epinephrine-induced platelet aggregation