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Acute fulminant pancreatitis was produced in dogs by injection of autobile into the mainpancreatic duct.After injection the phospholipase A_2(PLA_2)activities in serum,lung lymph andbronchoalveolar lavage fluid(BAL)were elevated significantly,lung lymph flow and pulmonarytransvascular potein clearance increased progressively,protein content and cell numbers in BAL inthe experimental animals were significantly higher than those in the control animals.Furthermore thelung index,wet to dry lung weight ratio,extravascular lung water to bloodless dry lung weight ra-tio,extravascuar lung water to bloodless dry lung weight ratio increased significantly as comparedto control animals.Pretreatment with PLA_2 inhibitor,chloroquine,blocked the changes mentionedabove.This experiment suggests:1.PLA_2 activity in lung lymph fluid as well as in serum andBAL is elevated in acute hemorrhagic pancreatitis.2.Elevated PLA_2 activity may increase thepulmonary vascular permeability.3.PLA_2 is the major factor leading to pulmonary edema in acutehemorrhagic pancreatitis.4.Phagocytes contribute to the lung injury induced by PLA_2 to some ex-tent.
Acute fulminant pancreatitis was produced in dogs by injection of autobile into the main pancreatic duct. After injection of the phospholipase A_2 (PLA 2) activities in serum, lung lymph and bronchoalveolar lavage fluid (BAL) were elevated significantly, lung lymph flow and pulmonary transvascular potein clearance increased progressively, protein content and cell numbers in BAL inthe experimental animals were significantly higher than those in the control animals. Future and more lung indicators weight ratio increased significantly as compared to control animals.Pretreatment with PLA_2 inhibitor, chloroquine, blocked the changes mentionedabove. This experiment suggests: 1.PLA_2 activity in lung lymph fluid as well as in serum and BAL is elevated in acute hemorrhagic pancreatitis.2. Elevated PLA_2 activity may increase the pulmonary vascular permeability.3. PLA2 is the major factor leading to pulmonary edema in acute hemorrhagic pancreatitis. 4.Phagocytes contribute to the lung injury induced by PLA_2 to some ex-tent.