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目的分析果胶铋联合阿莫西林与果胶铋联合克拉霉素两种方案治疗慢性萎缩性胃炎的临床疗效。方法将河南省濮阳市红十字医院收治的112例慢性萎缩性胃炎患者随机分为观察组(56例)和对照组(56例)。在常规治疗的基础上,观察组患者应用果胶铋联合阿莫西林方案治疗,对照组患者应用果胶铋联合克拉霉素方案治疗。评价两组患者的临床治疗效果;于两组患者治疗前后检测血清胃蛋白酶原亚群的指标值。采用SPSS 20.0统计软件,计量资料采用(x±s)表示,组间两组数据应用t检验方法,计数资料以率(%)表示,应用χ2检验。P<0.05为差异有统计学意义。结果观察组患者临床治疗的总有效率为91.07%、对照组为78.57%,两组比较差异有统计学意义(P<0.05);治疗前,两组患者的平均血清胃蛋白酶1、胃蛋白酶原2、胃蛋白酶原1/胃蛋白酶原2指标值比较,差异无统计学意义(P>0.05);治疗后,两组患者上述指标值均改善(P<0.05),但观察组患者各指标的改善幅度均大于对照组(P<0.05)。观察组患者恶心、头晕、皮疹不良反应的总发生率为7.14%,对照组为10.72%,两组比较,差异无统计学意义(P>0.05)。结论果胶铋联合阿莫西林治疗慢性萎缩性胃炎的临床疗效显著。
Objective To analyze the clinical effects of bismuth pectate combined with amoxicillin and pectin bismuth combined with clarithromycin in the treatment of chronic atrophic gastritis. Methods One hundred and twelve patients with chronic atrophic gastritis admitted in Puyang Red Cross Hospital of Henan Province were randomly divided into observation group (56 cases) and control group (56 cases). On the basis of routine treatment, patients in the observation group were treated with bismuth pectate combined with amoxicillin regimen, and patients in the control group were treated with bismuth pectate combined with clarithromycin. The clinical efficacy of two groups of patients was evaluated. The serum pepsin subgroups were measured before and after treatment in both groups. Using SPSS 20.0 statistical software, measurement data using (x ± s), said two sets of data between groups using t test method, the count data in%, said the application of χ2 test. P <0.05 for the difference was statistically significant. Results The total effective rate of clinical treatment was 91.07% in observation group and 78.57% in control group, with significant difference between the two groups (P <0.05). Before treatment, mean serum pepsin1, pepsinogen 2, pepsinogen 1 / pepsinogen 2 index values, the difference was not statistically significant (P> 0.05); after treatment, the two groups of patients were improved in the above indicators (P <0.05), but the observation group of patients with various indicators The extent of improvement was greater than that of the control group (P <0.05). The total incidence of nausea, dizziness and rash in the observation group was 7.14% and in the control group was 10.72%. There was no significant difference between the two groups (P> 0.05). Conclusion pectin bismuth combined with amoxicillin in the treatment of chronic atrophic gastritis clinical efficacy significantly.