论文部分内容阅读
目的研究76例脑胶质瘤的p53、CerbB－2和PCNA表达意义及其相关性。方法应用SP微波免疫组化技术和统计学分析。结果（1）在76例脑胶质瘤组织中，p53、CerbB－2和PCNA的阳性表达率分别是44．74％（34／76）、34．21％（26／76）和80．26％（61／76）。（2）p53的表达强度与胶质瘤的组织学类型和恶性程度呈显著正相关（P＜0．01）。（3）p53、CerbB－2和PCNA三者之间有阳性表达相关性（P＜0．05）。结论（1）P53的异常表达影响瘤细胞的分化，可能是胶质瘤的恶性表型和诊断指标之一。（2）CerbB－2的异常表达与p53异常有关，在胶质瘤生长中起重要作用。（3）多项癌基因的检测有助于脑胶质瘤的病理分析和生物学行为观察。
Objective To study the expression of p53, CerbB-2 and PCNA in 76 cases of gliomas and their correlation. Methods SP immunohistochemistry and statistical analysis. Results (1) The positive rates of p53, CerbB-2 and PCNA in 76 glioma tissues were 44.74% (34/76), 34.21% (26/76) and 80.26 % (61/76). (2) There was a significant positive correlation between the expression of p53 and the histological type and malignancy of glioma (P <0.01). (3) There was a positive correlation between p53, CerbB-2 and PCNA (P <0.05). Conclusion (1) Abnormal expression of P53 affects the differentiation of tumor cells, which may be one of the malignant phenotypes and diagnostic indicators of gliomas. (2) The abnormal expression of CerbB-2 is related to the abnormality of p53, which plays an important role in the growth of glioma. (3) The detection of multiple oncogenes contributes to the pathological analysis and biological behavior observation of glioma.