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采用固相酶联免疫吸附法对３５例急性期格林－巴利综合征（ＧＢＳ）患者、２８例其他神经系统疾病患者和３０例健康体检者的血清中抗硫脂抗体，抗ＧＱ１ｂ及抗ＧＭ１抗体进行检测。结果：ＧＢＳ患者血清中抗硫脂ＩｇＭ抗体、抗ＧＱ１ｂＩｇＧ抗体和抗ＧＭ１ＩｇＧ抗体阳性率分别为３４％、１１％和３１％，均显著高于正常对照组。５６％的抗硫脂抗体阳性患者均有不同程度感觉障碍，而抗硫脂抗体阴性患者仅１６％（Ｐ＜０．０５）。５例有眼肌运动障碍的ＧＢＳ患者中，４例抗ＧＱ１ｂＩｇＧ抗体阳性，无眼肌麻痹的ＧＢＳ患者无１例抗ＧＱ１ｂ抗体阳性。提示不同的抗糖脂抗体可能在ＧＢＳ发病过程中起不同的作用。
The anti-thrombolysin, anti-GQ1b and anti-GM1 antibodies in sera of 35 patients with acute Guillain-Barre syndrome (GBS), 28 patients with other neurological diseases and 30 healthy subjects were analyzed by solid phase enzyme-linked immunosorbent assay Antibody detection. Results: The positive rates of serum anti-thromboxane IgM, anti-GQ1b IgG and anti-GM1 IgG antibodies in GBS patients were 34%, 11% and 31% respectively, which were significantly higher than those in the normal control group. Fifty-six percent of patients with anti-thio lipid-positive antibodies had varying degrees of sensory disturbances, whereas only 16% were anti-sulfidemic antibody-negative patients (P <0.05). Of the 5 GBS patients with oculomotor dyskinesia, none of 4 GBS patients with anti-GQ1b IgG antibody and no ophthalmoplegia had anti-GQ1b antibody positive. Tip different anti-glycolipid antibodies may play a different role in the pathogenesis of GBS.