论文部分内容阅读
目的 观察系统性红斑狼疮 (SL E)患者体内的高凝状态和应用肝素治疗的效果。方法 测定 40例活动期 SL E患者血浆中纤维蛋白原 (Fg)、纤维蛋白降解产物 (FDP)、D二聚体 (D- D)的含量 ,并对其中 2 0例应用小剂量肝素 (6 2 5 0 U/d)治疗 ,2周后再次测定患者血浆中以上 3项指标。结果 40例 SL E患者 D- D含量明显增高 ,与正常组相比差异有显著性 (P<0 .0 1) ;FDP阳性 31例 ,占 77% ;Fg含量增高 19例 ,占 47.1% ,但无组间差异 (P>0 .0 5 )。 2 0例小剂量肝素治疗前后对比 ,3项指标均差异有显著性 (P<0 .0 1)。结论 本组结果支持 SL E有血栓形成的倾向 ,所测定的 3项血浆纤维蛋白溶解系统变化指标中以 D- D敏感 ,可作为反映 SL E高凝状态的敏感指标。在疾病活动期小剂量肝素短期治疗可作为一种有效的辅助治疗手段
Objective To observe the hypercoagulability in patients with systemic lupus erythematosus (SL E) and the effect of heparin treatment. Methods Plasma levels of fibrinogen (Fg), fibrin degradation product (FDP) and D dimer (D-D) were measured in 40 patients with active SL and 20 of them were treated with low-dose heparin 250 U / d) treatment, two weeks after the determination of plasma in patients with more than three indicators. Results The level of D-D in 40 patients with SL E was significantly higher than that in the normal group (P <0.01). FDP was positive in 31 patients (77%), Fg increased in 19 patients (47.1%), But no difference between groups (P> 0.05). 20 low-dose heparin compared before and after treatment, three indicators were significantly different (P <0.01). Conclusion The results of this group support the tendency of thrombosis of SL E. The three markers of plasma fibrinolytic system, which are sensitive to D-D, can be used as sensitive indicators to reflect the hypercoagulability of SL E. Short-term treatment of low-dose heparin in the disease activity can be used as an effective adjuvant therapy