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目的了解新疆乌苏市美沙酮维持治疗(MMT)门诊患者的丙型肝炎病毒(HCV)感染现状及影响因素,为制定相应干预措施提供依据。方法对2010—2014年在乌苏市美沙酮维持治疗门诊接受治疗的314名患者采集静脉血进行HCV抗体检测。结果 5年共检测314人,检出HCV抗体阳性132例,检出率42.04%,不同性别的吸毒人员抗体阳性率差异有统计学意义(χ2=4.763,P<0.05);比较开始吸毒年龄,20岁以下组检出率高于其他年龄组,差异有统计学意义(χ2=6.581,P<0.05);吸毒年限即毒龄20年以上组,抗体阳性率高于其他组,差异有统计学意义(χ2=19.730,P<0.05);有注射吸毒行为人群抗体检出率更高,差异有统计学意义(χ2=110.627,P<0.05);2010—2014年乌苏市抗体检测阳性率分别为40.68%、53.48%、49.15%、36.36%和38.10%,各年份差异无统计学意义(χ2=5.462,P>0.05)。结论乌苏市美沙酮维持治疗(MMT)门诊患者HCV感染率较高,应在全市加强预防丙型肝炎的宣传教育及行为干预。
Objective To understand the current status and influencing factors of hepatitis C virus (HCV) infection in methadone maintenance treatment (MMT) outpatients in Wusu, Xinjiang and provide the basis for formulating corresponding interventions. Methods A total of 314 patients treated in the Methadone Maintenance Treatment Clinic in Wusu from 2010 to 2014 were enrolled in the venous blood for HCV antibody detection. Results A total of 314 samples were detected in 5 years. The positive rate of anti-HCV antibody was 132.04% (positive rate was 42.04%). There was significant difference in the antibody positive rate among different drug users (χ2 = 4.763, P <0.05) The detection rate of the patients under the age of 20 was higher than other age groups, the difference was statistically significant (χ2 = 6.581, P <0.05); the age of drug abuse was more than 20 years old, antibody positive rate was higher than other groups, the difference was statistically (Χ2 = 19.730, P <0.05). The detection rate of antibodies in injecting drug users was higher (χ2 = 110.627, P <0.05). The positive rate of antibodies in Usu Which was 40.68%, 53.48%, 49.15%, 36.36% and 38.10% respectively. There was no significant difference between years (χ2 = 5.462, P> 0.05). Conclusion The prevalence of HCV infection in methadone maintenance treatment (MMT) outpatients in Wusu City should be higher than that in other cities. Publicity education and behavioral intervention should be strengthened throughout the city.