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目的探讨钝挫伤性视网膜、脉络膜循环障碍及复方樟柳碱（ｃｏｍｐｏｕｎｄａｎｉｓｏｄｉｎｅ，ＣＡ）治疗机理。方法用自由落体打击，损伤能量３．３Ｊ，造成兔轻度眼球钝挫伤模型。在不同时间点，用放射免疫法测定伤眼及对侧眼视网膜、脉络膜免疫活性内皮素（ｉｍｍｕｎｏｒｅａｃｔｉｖｅ－ｅｎｄｏｔｈｅｌｉｎ，ｉｒ－ＥＴ）水平。结果生理盐水及托拉苏林组伤后３ｄ视网膜ｉｒ－ＥＴ降低（Ｐ＜０．０５）。伤后１ｄ脉络膜ｉｒ－ＥＴ下降，３ｄ降至最低水平（Ｐ＜０．０５～０．０１），７ｄ各组均趋于正常。ＣＡ组视网膜、脉络膜ｉｒ－ＥＴ水平基本波动在正常范围（Ｐ＞０．０５）。从而避免和减轻挫伤性视网膜、脉络膜缺血。对侧眼变化与伤眼基本平行（Ｐ＞０．０５）。结论眼球钝挫伤使伤后早期视网膜、脉络膜ｉｒ－ＥＴ水平降低，可能是造成钝挫伤性视网膜、脉络膜循环障碍的因素之一。ＣＡ早期应用可稳定ｉｒ－ＥＴ水平，托拉苏林无此治疗作用。对侧眼ｉｒ－ＥＴ变化是眼的同感反应所致。
Objective To investigate the mechanism of blunt traumatic retina, choroidal circulation disturbance and compoundanisodine (CA) treatment. Methods Free-fall combat, damage energy 3.3J, resulting in rabbit mild eye contusion injury model. At different time points, the levels of immunoreactive-endothelin (ir-ET) in injured eyes and contralateral eye retina and choroid were measured by radioimmunoassay. Results Retinal ir-ET was decreased in the saline and torethaurine groups (P <0.05). At 1 day after injury, the choroidal ir-ET level decreased to the lowest level on 3d (P <0.05 to 0.01), and all the groups on the 7th day tended to be normal. The level of retinal and choroidal ir-ET in CA group fluctuated within the normal range (P> 0.05). To avoid and reduce contusion of the retina, choroidal ischemia. Contralateral eye changes and injury basically parallel (P> 0.05). Conclusions Eye contusion may reduce the level of early retina and choroidal ir-ET, which may be one of the factors that cause blunt traumatic retinal and choroidal circulation disorders. Early application of CA stabilizes ir-ET levels, but there is no therapeutic effect of tolazarin. Opposite eye ir-ET changes are due to the same eye reaction.