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胆道结石是消化系统常见疾病，目前主要治疗手段有外科手术、内镜下介入治疗等，但部分困难结石临床上仍面临挑战。双频双脉冲激光碎石术因其安全、高效等特点，是解决困难结石的有效方法。双频双脉冲掺钕钇铝石榴石激光是目前被国家药品监督管理局批准的可用于胆道结石碎石的激光技术，但其适应证、导入方式和操作规范等问题尚未形成共识。为此，国家消化系统疾病临床医学研究中心(上海)、中国医师协会内镜医师分会和中华医学会消化内镜学分会特邀国内消化、内镜与外科等相关领域专家，在参考国内外文献的基础上，经过充分讨论形成本专家建议，以期为国内规范开展胆道结石激光碎石提供指导和参考。“,”Biliary calculi is one of the common digestive disorders. The major therapeutic options of biliary calculi include surgery and endoscopic intervention, but challenges still exist in the treatment of certain difficult stones. With the advantages of safety and high efficiency, frequency-doubled double pulse laser lithotripsy is considered an effective method to solve difficult stones. The frequency-doubled double pulse neodymium-doped yttrium aluminum garnet laser has been approved by the State Drug Administration for lithotripsy of biliary stones. However, there is no consensus on its indications, introduction methods and operating specifications yet. Therefore, on the basis of reference to literatures, the National Clinical Research Center for Digestive Diseases (Shanghai), Endoscopy Professional Committee of Chinese Endoscopist Association and Chinese Society of Digestive Endoscopy organized domestic experts in relevant fields to formulate this expert opinion after full discussion. This expert opinion may provide some guidance and references for the standard conduction of laser lithotripsy for biliary stones in China.