【摘 要】
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目的 探讨奥氮平辅助治疗难治性抑郁症患者的疗效及对生活质量的影响.方法 68例难治性抑郁症患者随机分为研究组(奥氮平+舍曲林n=34)和对照组(单用舍曲林n=34),疗程8周.以汉
【机 构】
：
河南省驻马店市精神病医院,463000
论文部分内容阅读
目的 探讨奥氮平辅助治疗难治性抑郁症患者的疗效及对生活质量的影响.方法 68例难治性抑郁症患者随机分为研究组(奥氮平+舍曲林n=34)和对照组(单用舍曲林n=34),疗程8周.以汉密尔顿抑郁量表(HAMD)及不良反应量表(TESS) 分别在治疗前及治疗第1、2、4、6和8周末各评定1次,以生活质量综合问卷(GQOLI-74)在治疗前和治疗后8周末各评定一次生活质量.结果 研究组于第1周末起效,对照组于第2周末起效,治疗后1、2、4、6周末HAMD评分差异有统计学意义(P0.05).8周末,研究组除物质生活维度外,其他维度得分明显高于对照组,有显著性差异(P<0.01).结论 奥氮平辅助治疗难治性抑郁症起效快,可增加疗效,优于单用舍曲林治疗,且明显改善患者的生活质量.
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