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目的观察正常妊娠妇女体内甲状腺过氧化物酶抗体(TPOAb)水平,以及与促甲状腺激素(TSH)水平变化之间的关系,并探讨其在产前筛查的价值。方法选取463例孕妇(孕周12~24周),采用化学发光法(CIA)检测促甲状腺激素(TSH)和甲状腺过氧化物酶抗体(TPOAb)水平,以TPOAb值<9IU/ml为正常范围,根据TPOAb测定结果,将463例孕妇分为阳性组53例,和阴性组410例。结果 53例TPOAb阳性的孕妇,其中有5例TSH异常(9.43%),410例TPOAb阴性的孕妇,其中12例TSH异常(2.92%),其异常率有统计学意义(P<0.05)。结论 TPO阳性孕妇甲状腺功能紊乱明显增加,TPOAb阳性孕妇的甲状腺功能有向亚临床甲状腺功能减退的趋势。
Objective To observe the level of thyroid peroxidase antibody (TPOAb) in normal pregnant women and the relationship with the level of thyroid stimulating hormone (TSH) and to explore its value in prenatal screening. Methods 463 pregnant women (gestational weeks 12-24 weeks) were selected. The thyroid-stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb) levels were measured by chemiluminescence (CIA). The TPOAb value <9IU / According to the result of TPOAb, 463 pregnant women were divided into positive group (n = 53) and negative group (n = 410). Results Among 53 TPOAb positive pregnant women, there were 5 pregnant women with TSH abnormality (9.43%) and 410 pregnant women with TPOAb negative pregnancy (12.9%). The abnormality rate of TSH in 12 cases was statistically significant (P <0.05). Conclusions Thyroid dysfunction was significantly increased in TPO positive pregnant women, and thyroid function in TPOAb positive pregnant women tended to have sub-clinical hypothyroidism.