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1898年Tigerstedt和Bergman将兔肾提取物注射给另一只兔,引起了血压升高,因而认为肾性高血压是由一种称为“肾素”的物质所致,由此,作者将高血压与肾脏联系起来。1934年Goldblatt通过使肾动脉狭窄而引起高血压的实验也证实了前者的观点。当时认为血浆肾素水平增高是肾性高血压的主要原因。后来人们发现90%以上肾性高血压病人其血浆肾素水平并不高,而认为血容量增多是其主要原因。Safer等还发现在慢性肾炎肾功能衰竭的病人,高血压是血浆肾素与血容量两者平衡失调的结果。Neal等也提出肾
In 1898, Tigerstedt and Bergman injected a rabbit kidney extract into another rabbit, causing an increase in blood pressure, and therefore renal hypertension was thought to be caused by a substance called “renin,” whereby the author set high Blood pressure is linked to the kidneys. Goldblatt’s experiment of causing hypertension in 1934 by narrowing the renal arteries also confirmed the former’s view. At that time, it was thought that the increase of plasma renin was the main reason of renal hypertension. Later, it was found that more than 90% of patients with renal hypertension, plasma renin levels are not high, and that increased blood volume is the main reason. Safer et al also found that in patients with chronic nephritis and renal failure, hypertension is the result of a dysregulation of plasma renin and blood volume. Neal et al also propose kidney