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目的:研究癌痛消颗粒对大鼠的长期毒性作用。方法:癌痛消颗粒以临床成人日用量的27.44、13.72、5.49倍连续灌服12周,停药2周,分别称量大鼠体重,计算脏器系数,测定血液学和血液生化学指标,并做病理组织学检查。结果:癌痛消颗粒高、中、低剂量组动物的外观行为、体重、脏器系数、血常规和血生化学指标与空白对照组比较均无明显差异;对凝血指标有延长作用,其影响具有可逆性。病理检查未见与药物毒性相关的明显病变,停药后也未见药物延迟性毒性反应。结论:癌痛消颗粒长期用药对大鼠无明显毒性,推论临床拟用剂量是安全的。
Objective: To study the long-term toxicity of Jiaotongxiao granules in rats. Methods: Guatongxiao granule was fed continuously for 27 weeks, 27.74 times and 5.59 times daily for 12 weeks. The rats were taken out of medicine for 2 weeks. The body weight was weighed, the organ coefficient was calculated, the hematology and blood biochemistry indexes were measured, And histopathological examination. Results: The appearance behavior, body weight, organ coefficient, blood and blood biochemical indexes in the groups of high, medium and low dose of Jiaotongxiao granules had no significant difference compared with the blank control group, but had the effect of prolonging the coagulation index Reversible. Pathological examination showed no obvious pathological changes associated with drug toxicity, delayed drug-induced delayed drug-induced toxicity. Conclusion: The long-term use of Jiaotongxiao granules has no obvious toxicity on rats, and it is concluded that the dosage to be used clinically is safe.