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目的观察和分析唐氏筛查在产前中的应用价值。方法随机选取产前筛查的妊娠中期(15~20周)孕妇12422例,给予唐氏筛查且对筛查结果、染色体核型等进行观察和数据的相关分析。结果唐氏综合征筛出率与年龄呈正相关性(r=4.059,P<0.05);448例唐氏筛查高风险孕妇中171例进行产前羊水穿刺诊断,其中胎儿细胞培养染色体核型结果异常者10例,阳性检出率为5.85%;高风险孕妇核型异常率分别相比后,差异无统计学意义(P>0.05)。结论唐氏筛查作为一种无创性产前筛查方法,能有效防止染色体疾病和先天缺陷儿的出生,在产前筛查与诊断中具有重要价值,值得推广。
Objective To observe and analyze the application value of Down’s screening in prenatal period. Methods We randomly selected 12,422 pregnant women of prenatal screening during the second trimester of pregnancy (15 to 20 weeks), were given Down’s screening and the correlation analysis between screening results and chromosomal karyotype were conducted. Results The screening rate of Down Syndrome was positively correlated with age (r = 4.059, P <0.05). The prenatal amniocentesis was diagnosed in 171 out of 448 high risk pregnant women with Down’s syndrome screening. Among them, the fetal karyotype results 10 cases were abnormal and the positive rate was 5.85%. There was no significant difference in the karyotype frequency of high-risk pregnant women (P> 0.05). Conclusion As a noninvasive prenatal screening method, Down’s screening can effectively prevent the birth of chromosomal diseases and birth defects, which is of great value in prenatal screening and diagnosis and is worthy of promotion.