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致使放疗失败的原因之一是肿瘤内存在放射抗性的细胞,从大量细胞系实验分析中已证明,人类肿瘤细胞系低剂量存活参数与不同类型肿瘤组织的临床放射敏感性相关.这一结论可作为预测肿瘤放疗可治愈性的根据.本文作者报告了72例头颈部鳞状细胞癌(SCC)原代培养的S_2值(2.0Gy照射存活)和肿瘤局部控制之间的关系.121例均为外科手术和术后放疗的头颈部鳞状细胞癌患者,取其外科标本和活检组织进行肿瘤细胞原代贴壁培养.其中106例培养出足够测定放射敏感性的细胞数量,能评价结果的培养
One of the reasons for the failure of radiotherapy is the presence of radioresistant cells in the tumor. It has been demonstrated from a large number of cell line assays that the low-dose survival parameters of human tumor cell lines correlate with the clinical radiosensitivity of different types of tumor tissue Can be used as a basis for predicting the tumor radiotherapy curability.This paper reports 72 cases of head and neck squamous cell carcinoma (SCC) primary culture S_2 value (2.0Gy irradiation survival) and the relationship between the local control of the tumor.121 cases Surgical and postoperative radiotherapy of patients with squamous cell carcinoma of the head and neck squamous cell carcinoma, surgical specimens and biopsy specimens were taken for primary adherence of tumor cells, of which 106 cases were sufficient for radiosensitization and could be evaluated Results of the training