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Poverty eradication is a realistic requirement for the addressing of the urban-rural development imbalance. It consolidates the achievements of the poverty alleviation, and accelerates the realization of the United Nations Sustainable Development Goals. In re-search that deals with poverty, qualitative analysis is often used to study the connection between a single influencing factor and poverty reduction, and to solve regional poverty through government measures. However, these studies usually ignore the multidimensional nature of poverty, and the fact that poverty alleviation also needs to be approached from multiple perspectives. By constructing a theor-etical framework of poverty alleviation performance from the perspective of sustainable development, this study selects contiguous poverty-stricken areas in the Hunan Province, China as the empirical study area, constructs an evaluation index system from the three di-mensions of economic development, infrastructure and people’s livelihood security, and selects influencing factors from three aspects of‘population’, ‘land’ and ‘industry’. The spatial differentiation characteristics and influencing factors of poverty alleviation performance in poverty-stricken areas were studied by using the methods of entropy weight method and geodetector. The results show: firstly, in the concentrated and contiguous poverty-stricken areas of the Hunan Province, the performance of poverty alleviation in the economic de-velopment makes little difference, showing a ‘high-medium-low’ cross-distribution pattern. The poverty alleviation performance of the infrastructure presents a distribution pattern of ‘low in the middle and high on both sides. The poverty alleviation performance of people’ s livelihood security has significant spatial differentiation characteristics, which all present a reunion distribution. The overall poverty al-leviation performance varies greatly, showing a funnel-shaped distribution in space. Secondly, the spatial differentiation of poverty alle-viation performance in the concentrated and contiguous poverty-stricken areas of the Hunan Province is the result of the combined ef-fects of multiple factors. ‘Population’ is the dominant factor affecting the performance of poverty alleviation, ‘land’ is the basic factor that causes the spatial differentiation of poverty alleviation performance, and ‘industry’ is the key factor for the improvement of the poverty alleviation ability.