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目的探讨纳洛酮联合高压氧治疗新生儿缺血缺氧性脑病(HIE)的临床疗效。方法回顾性分析2014年1月-2015年2月收治的75例缺氧缺血性脑病患儿的临床资料,将75例HIE患儿随机分为观察组38例与对照组37例,对照组给予常规治疗,观察组在对照组治疗的基础上给予纳洛酮联合高压氧治疗,对2组患儿的临床治疗效果进行对比分析。结果观察组总有效率为94.74%明显高于对照组的75.68%,差异有统计学意义(P<0.05)。结论纳洛酮联合高压氧治疗新生儿缺氧缺血性脑病,可以明显改善患儿的早期症状,缩短治疗周期,且不良反应少,安全性高,值得临床上推广应用。
Objective To investigate the clinical effect of naloxone combined with hyperbaric oxygen on neonatal hypoxic-ischemic encephalopathy (HIE). Methods The clinical data of 75 children with hypoxic ischemic encephalopathy admitted from January 2014 to February 2015 were retrospectively analyzed. Thirty-seven children with HIE were randomly divided into observation group (38 cases) and control group (37 cases), control group The patients in the observation group were treated with naloxone and hyperbaric oxygen on the basis of the control group, and the clinical effects of the two groups were compared. Results The total effective rate of the observation group was 94.74%, which was significantly higher than that of the control group (75.68%), the difference was statistically significant (P <0.05). Conclusion Naloxone and hyperbaric oxygen treatment of neonatal hypoxic-ischemic encephalopathy can significantly improve children’s early symptoms and shorten the treatment cycle, and fewer adverse reactions, high safety, it is worth promoting the clinical application.