论文部分内容阅读
天然免疫在机体抗病毒感染的过程中发挥重要作用。近年来,识别和感受病原体的一系列模式识别受体受到广泛关注,TLR(Toll-like receptor)便是这一领域中的热点,随着研究的深入,一类TLR非依赖性模式识别受体,逐渐活跃在天然免疫识别的舞台,这其中,解旋酶(helicase)家族中的重要成员——维甲酸诱导基因I(retinoic acid-inducedgeneI,RIG-I),主要识别并直接结合到某些5'端磷酸化RNA病毒,通过蛋白质-蛋白质接触方式,与其受体MAVS(mitochondrial antiviral signaling protein)也称作VISA(virus induced signaling adaptor)、IPS-1(IFN-promoter stimulating factor)或Cardif结合,活化TBK1和IKKe,激活转录因子NF-kB、IRF-3,引起I型干扰素分泌上调,发挥抗病毒效应。RIG-I途径除了在天然免疫中发挥抗病毒作用以外,也是一些病毒逃逸机体免疫的靶点,如HCV、HAV、GB病毒等。
Natural immunity plays an important role in the process of antiviral infection in the body. In recent years, a great deal of attention has been paid to a series of pattern recognition receptors that recognize and recognize pathogens. Toll-like receptors (TLRs) are the hotspots in this field. With further research, a class of TLR-independent pattern recognition receptors , And gradually became active in the field of innate immune recognition. Among them, retinoic acid-induced gene I (RIG-I), an important member of the helicase family, mainly recognizes and directly binds to certain The 5'-terminal phosphorylated RNA virus binds to its receptor MAVS (also known as VISA (virus induced signaling adapter), IPS-1 (IFN-promoter stimulating factor) or Cardif through protein-protein contact, Activation of TBK1 and IKKe, activation of transcription factors NF-kB, IRF-3, causing type I interferon upregulation, play antiviral effects. RIG-I pathway in addition to play an anti-virus role in innate immunity, but also some of the virus escape the body's immune targets, such as HCV, HAV, GB virus.