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目的:探讨宫颈鳞状细胞癌中凋亡凋控因子Survivin和Caspase-3蛋白的表达及其意义。方法:采用免疫组织化学技术检测40例宫颈鳞状细胞癌及lO例正常宫颈组织中Survivin和Caspase-3的表达水平。结果:Survivin蛋白在宫颈鳞状细胞癌中表达水平高于正常宫颈组织(P<0.05)。Caspase-3表达水平低于正常宫颈组织(P<0. 05)。Survivin和Caspase-3蛋白的表达水平在不同分化程度的宫颈癌之间的差异有显著意义(P<0.05)。结论:宫颈鳞状细胞癌的发生、发展与Survivin和Caspase-3蛋白的异常表达有关,可能是细胞异常增殖和凋亡失衡的结果。
Objective: To investigate the expression and significance of Survivin and Caspase-3 in cervical squamous cell carcinoma. Methods: Immunohistochemical technique was used to detect the expression of Survivin and Caspase-3 in 40 cases of cervical squamous cell carcinoma and 10 cases of normal cervical tissue. Results: The expression of Survivin protein in cervical squamous cell carcinoma was higher than that in normal cervical tissues (P <0.05). Caspase-3 expression was lower than normal cervical tissue (P <0.05). The difference of the expression of Survivin and Caspase-3 between cervical cancer with different degree of differentiation was significant (P <0.05). Conclusion: The occurrence and development of cervical squamous cell carcinoma are related to the abnormal expression of Survivin and Caspase-3 protein, which may be the result of abnormal cell proliferation and apoptosis imbalance.