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目的 探讨外周α受体是否影响慢性应激对颈动脉窦反射 (CSR)的重调定。方法 应激 1周的大鼠 ,麻醉后孤离双侧颈动脉窦区 ,将不同窦内压 (ISP)与其对应的平均动脉压 (MAP)值进行Logistic曲线拟合 ,求得ISP -MAP关系曲线及其特征参数 ,观察外周静脉注射 (iv)α受体拮抗剂酚妥拉明 (PHEN)对CSR的影响。结果 (1)ivPHEN(2 0 μg/ 10 0g体重 )导致应激大鼠ISP MAP关系曲线的后半程显著下移 ,反射参数中阈压 (TP)、饱和压 (SP)和最大增益时的窦内压 (ISPGmax)值均减少 (P <0 .0 5 )。 (2 )iv相同剂量的PHEN对非应激大鼠的CSR无明显影响。(3)ivPHEN不能使应激的CSR水平恢复到非应激给药后水平。结论 外周α受体参与慢性应激对CSR的重调定。
Objective To investigate whether peripheral α receptors affect the resolution of carotid sinus reflex (CSR) by chronic stress. Methods Rats under stress for 1 week were anesthetized and isolated from both sides of the carotid sinus. Logistic curve fitting was performed between different sinus pressure (ISP) and its corresponding mean arterial pressure (MAP), and the ISP-MAP relationship Curve and its characteristic parameters to observe the influence of peripheral intravenous injection (iv) of α-receptor antagonist phentolamine (PHEN) on CSR. Results (1) ivPHEN (20 μg / 100 g body weight) led to a significant decrease in the second half of the ISP MAP curve in stress rats. The threshold pressure (TP), saturation pressure (SP) Sinus internal pressure (ISPGmax) values were reduced (P <0. 05). (2) iv The same dose of PHEN had no significant effect on CSR in non-stressed rats. (3) ivPHEN failed to restore stressful CSR levels to post-stress levels. Conclusions Peripheral alpha receptors are involved in the re-tuning of CSR to chronic stress.