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目的 探讨正常妊娠孕妇血液动力学变化规律及妊高征患者血液动力学的变化特点。 方法 应用无创伤心血管参数测量仪 (TP- CBS)对 896例妊娠妇女分别在妊娠早、中、晚期及产后序贯测定血液动力学有关参数 ,其中资料完整的正常妊娠 30 0例 (正常妊娠组 ) ,妊高征 97例 (妊高征组 ) ,并与 80例非孕妇女 (对照组 )进行对照研究。 结果 正常妊娠组在妊娠早期平均动脉压 (MAP)、心输出量 (CO)、心脏指数 (CI)、心搏量 (SV)、心搏指数 (SI)、及血管顺应性 (AC)均高于对照组 ,外周阻力 (TPR)和血粘度 (V)低于对照组 ,但均无统计学意义。妊娠中期 ,CO5 .0 5 L/ min,SI39.74ml/搏 .m2 ,明显高于对照组 (P<0 .0 5 )。TPR 1.0 2 PRU ,明显低于对照组 (P<0 .0 5 )。妊娠晚期 (2 8～ 32周 ) ,血液动力学各参数均发生更明显变化 :CO 5 .5 6 L / m in,SI 42 .49m l/搏 .m2 ,TPR 0 .96 PRU ,AC1.83m l/ mm Hg(P<0 .0 1) ,并持续到妊娠晚期 (>36周 )。产后 1周 ,CO、SV、SI、AC仍与对照组有显著差异 (P<0 .0 5 )。妊高征患者在妊娠早期各参数与正常妊娠组无显著差异。妊娠中期 ,MAP 90 .2 2mm Hg,TPR 1.2 3PRU,V 4.39CP,明显高于正常妊娠组 (P<0 .0 5 )。妊娠晚期 ,CO 5 .2 2 L / m in,SI 38.6 4m l/搏 .m2 ,AC 1.2
Objective To investigate the changes of hemodynamics and the changes of hemodynamics in pregnant women with normal pregnancy. Methods Serum parameters of 896 pregnant women were determined in the early, middle, late and postpartum period respectively by using the noninvasive cardiovascular parameter measuring instrument (TP-CBS). Among them, 30 cases of normal pregnancy with complete data (normal pregnancy group ), PIH97 cases (PIH group), and compared with 80 non-pregnant women (control group) control study. Results The mean arterial pressure (MAP), cardiac output (CO), cardiac index (CI), stroke volume (SV), cardiac index (SI) and vascular compliance (AC) In the control group, peripheral resistance (TPR) and blood viscosity (V) were lower than those in the control group, but none of them was statistically significant. In the second trimester of pregnancy, the CO5. 05 L / min, SI39.74ml / stroke .m2 was significantly higher than that of the control group (P <0.05). TPR 1.0 2 PRU, significantly lower than the control group (P <0. 05). In the third trimester of pregnancy (28 to 32 weeks), the parameters of hemodynamics all changed significantly: CO 5 .5 6 L / min, SI 42.49 min / m 2, TPR 0.96 PRU, AC 1.83 m l / mm Hg (P <0.01), and continued until the third trimester of pregnancy (> 36 weeks). One week after delivery, CO, SV, SI and AC still had significant difference with the control group (P <0.05). PIH patients in the first trimester of pregnancy parameters and normal pregnancy no significant difference. In the second trimester of pregnancy, MAP 90 .2 2mm Hg, TPR 1.2 3PRU and V 4.39CP were significantly higher than those in the normal pregnancy group (P <0.05). In the third trimester of pregnancy, CO 5 .2 2 L / m in, SI 38.6 4 m l / stroke .m 2, AC 1.2