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目的：研究视网膜母细胞瘤（ｒｅｔｉｎｏｂｌａｓｔｏｍａ，ＲＢ）细胞分化程度及肿瘤扩散与预后的关系。方法：对８２例摘除眼球的ＲＢ病人临床、随访资料和病理标本进行调查研究，比较分化型与未分化型ＲＢ术后的病死率，不同扩散部位的病死率。记录死者术后存活时间及生存者的后遗症。结果：分化型ＲＢ病死率２７．２７％，未分化型为２２．５４％，眶内和巩膜侵犯病死率１００％，视神经侵犯Ⅳ级病死率６２．５％，葡萄膜侵犯病死率２２．２２％。死者术后平均生存时间２１．９２月。存活者主要存在面部整形问题。结论：ＲＢ预后与肿瘤细胞分化程度无明显关系，发生扩散的ＲＢ病人如能适当治疗，可提高生存率
Objective: To investigate the relationship between the degree of differentiation of retinoblastoma (RB) cells, tumor proliferation and prognosis. METHODS: The clinical, follow-up data and pathological specimens of 82 patients with RB with enucleation were investigated. The mortality of differentiating and undifferentiated RB postoperatively was compared, and the mortality rate at different diffusion sites was compared. The postoperative survival time and the survivors’ sequelae were recorded. Results: The mortality rate of differentiated RB was 27.27%, the undifferentiated type was 22.54%, the intrauterine and scleral invasion mortality rate was 100%, the grade IV mortality rate of optic nerve was 62.5%, and the uveal invasion mortality rate was 22.22. %. The average survival time of the deceased was 21.92 months. The survivors mainly suffer from facial cosmetic problems. Conclusions: The prognosis of RB is not significantly related to the degree of differentiation of tumor cells. RB patients with proliferative disease can improve survival if treated appropriately.